Reducing particle size has shown to overcome problems associated with poorly water-soluble compounds. Reducing below micron level – to the nanometer range offers appreciable advantages to compounds. Since dissolution rate is a function of surface area, a nano-formulation will have better bioavailability than a micronized formulation of the same drug.

Benefits of applying the NanoCrystal® Technology versus micronization techniques include:

• Enhancing oral bioavailability
• Increased therapeutic effectiveness
• Reducing /eliminating fed/fasted variability
• Optimizing delivery
• Increased absorption             

Respirable Fraction of Spray Dried NanoCrystal® particles vs. Micronized Drug Substance

The respirable fraction of spray dried NanoCrystal® particles are more than double that of micronized drug substance when delivered by the same dry powder inhaler.